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Promising results for Cabometyx in advanced neuroendocrine tumors

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Ipsen has announced final results from the Phase III CABINET trial, showing the efficacy of Cabometyx® (cabozantinib) in advanced neuroendocrine tumors. The data show a significant reduction in the risk of disease progression or death compared to placebo.

The study, presented at ESMO Congress 2024, demonstrates statistical and clinical benefits, with a 77% risk reduction for pancreatic neuroendocrine tumors and 62% for extrapancreatic neuroendocrine tumors. Median follow-up shows notable progression-free survival for patients treated with Cabometyx.

In response, Ipsen filed an application for an extension of indication with the European Medicines Agency. Given the limited treatment options for these tumors, these results could represent a significant advance.

R. E.

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